Application:
Nanoparticles, liposomes, or polymeric nanoparticles are used to deliver chemotherapy drugs. By targeting anticancer drugs to tumor tissues using nanocarriers, damage to normal cells is reduced, and the enhanced permeability and retention (EPR) effect increases drug concentration at the tumor site.
Technical Advantages:
Increases the accumulation of chemotherapy drugs in tumors, reducing side effects.
Nanocarriers can be modified with tumor-targeting ligands (e.g., antibodies, peptides) to enhance selectivity.
Controlled release technology enables continuous and stable drug delivery.
Application:
Nanoparticles (such as lipid nanoparticles or polymer nanoparticles) are used to deliver small interfering RNA (siRNA), messenger RNA (mRNA), or DNA for gene silencing, gene editing, or gene expression.
Technical Advantages:
Enhances the stability of gene drugs in the body, preventing rapid degradation.
Nanocarriers can enter the nucleus to facilitate efficient delivery of gene therapy drugs within cells.
Provides personalized treatment for specific genetic disorders, cancers, or viral infections.
Application:
Nanocarriers are used to deliver drugs for treating neurodegenerative diseases such as Alzheimer's and Parkinson's by leveraging their ability to cross the blood-brain barrier (BBB), improving drug targeting to the brain.
Technical Advantages:
Nanocarriers can cross the BBB, enabling drug delivery to the central nervous system.
Ligand modifications (such as antibodies, peptides, or aptamers) can further enhance targeting of brain-specific sites.
Offers sustained drug release, slowing disease progression.
Application:
Metal nanoparticles (such as silver nanoparticles) or liposome-based drug delivery systems are used to deliver antibacterial or antiviral drugs.
Technical Advantages:
Metal nanoparticles possess inherent antimicrobial activity and can kill pathogens through physical contact or the generation of reactive oxygen species.
Nanodrug delivery increases the local concentration of antibacterial agents at the infection site, reducing the development of drug-resistant strains.
In antiviral therapies, such as for HIV or influenza, enhanced targeted delivery boosts treatment efficacy.
Application:
Nanocarriers are used to deliver drugs for treating eye diseases such as glaucoma and macular degeneration. Examples include nanomicelles, liposomes, or polymeric nanoparticles loaded with anti-inflammatory drugs.
Technical Advantages:
Prolongs drug retention time in ocular tissues, enhancing therapeutic effects.
Surface modifications of nanoparticles (e.g., RGD peptides) allow specific targeting of corneal or retinal cells.
Controlled release technology reduces the frequency of local drug administration and improves patient compliance.
Application:
Nanocarriers are used to deliver drugs for treating cardiovascular diseases (e.g., statins or antithrombotic drugs), reducing atherosclerotic plaque, preventing thrombosis, or repairing vascular injury.
Technical Advantages:
Nanoparticles can specifically target damaged vascular areas, enhancing local treatment effects.
Reduces systemic side effects of drugs, especially in anticoagulant and antithrombotic treatments.
Sustained release technology decreases dosing frequency and provides longer-lasting therapeutic effects.
Application:
Nanocarriers are used to deliver insulin or immunomodulatory drugs (e.g., regulatory T cell-related drugs) for the treatment of Type 1 or Type 2 diabetes.
Technical Advantages:
Nanoparticles can deliver insulin via subcutaneous injection or oral administration, avoiding the inconvenience of traditional injections.
Targeted immune modulation can suppress the autoimmune response in Type 1 diabetes.
Smart nanocarriers can respond to blood glucose fluctuations, enabling on-demand insulin release.
Application:
Nanoparticles serve as platforms for vaccine delivery, carrying antigens or DNA vaccines to enhance immunogenicity and immune response.
Technical Advantages:
Improves the stability and efficacy of vaccines, enhancing the immune system’s response to antigens.
Surface modifications can enhance the targeting of vaccines to specific immune cells.
Used in the delivery of novel mRNA vaccines, increasing mRNA delivery efficiency and expression levels within the body.
Application:
Nanodrug delivery technology can be customized based on the patient's genetics, pathological characteristics, and treatment needs to ensure maximum drug targeting and efficacy.
Technical Advantages:
Personalized design of nanocarriers enables precise treatment for specific patients.
Reduces systemic drug side effects, increasing treatment specificity and safety.
Can be applied to diseases requiring personalized treatments, such as cancer and genetic disorders.
Application:
Liposomes and PLGA-modified nanovesicles are used for simultaneous imaging and therapy. By visualizing drug distribution at the target site, the effectiveness of drug delivery can be evaluated. A specific application is tracking immune cells used in immunotherapy to assess their ability to reach tumor sites.
Technical Advantages:
Enables real-time monitoring of drug distribution in the body, optimizing drug dosage and treatment strategies.
Enhances therapeutic efficacy while providing diagnostic information, advancing the development of theranostic technologies.
Application:
Nanocarriers are used to deliver drugs for treating cardiovascular diseases (e.g., statins or antithrombotic drugs), reducing atherosclerotic plaque, preventing thrombosis, or repairing vascular injury.
Technical Advantages:
Nanoparticles can specifically target damaged vascular areas, enhancing local treatment effects.
Reduces systemic side effects of drugs, especially in anticoagulant and antithrombotic treatments.
Sustained release technology decreases dosing frequency and provides longer-lasting therapeutic effects.
